Technische Universiteit Delft (TU Delft) contributes to solving complex and urgent societal challenges by pushing the boundaries of technical sciences, developing innovative applications, and fostering entrepreneurship. This is achieved through education of highly qualified, creative engineers, who are ambitious to make a real impact towards building a sustainable society. TU Delft conducts research at a world-class level by combining groundbreaking science, pioneering technologies and human-centered designs. The development of such technology-based innovations is made possible by applying the following values as our guiding principles: diversity, integrity, respect, engagement, courage and trust.
In PHOENIX, TU Delft in collaboration with project partners provides the technology, 3dFORCE, for the measurement of contractile properties of three-dimensional engineered heart tissues (EHTs) in vitro. Firstly, a method utilizing optical tracking of the displacement of microfabricated structures upon the contraction of the EHTs will be introduced. Secondly, a novel technology, 3dFORCE, allowing for the acquisition of electrical signals which can be directly related to the contractile function of the EHTs will be developed. Finally, 3dFORCE and 3dMEA will be integrated into an advanced 3D organ-on-chip model allowing for comprehensive real-time assessment of the (altered) cardiac contractility and muscular health.
Main contributions and activities:
Adriana Karcz – Postdoctoral researcher at Electronic Components, Technology and Materials (ECTM), department of Microelectronics, TU Delft
Massimo Mastrangeli – Associate Professor at ECTM, department of Microelectronics, TU Delft
