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NMI

NMI Natural and Medical Sciences Institute

Location: 🇩🇪 Reutlingen, Germany
Website: www.nmi.de
Type: Research Institute

Partner Identity

The NMI Natural and Medical Sciences Institute at the University of Tübingen is a non-profit research institute based in Reutlingen, Germany. We conduct application-oriented research at the interface of life sciences and materials science and translate new ideas into practical solutions for healthcare and industry. Together with companies and public research organizations, we develop innovative diagnostics, therapies, medical products and advanced materials. Our services range from contract research, consulting and technology assessment to support with funding applications, project coordination and accredited testing, making NMI a reliable bridge between academic research and real-world applications.

Role in PHOENIX

In PHOENIX, NMI provides advanced microelectrode sensor chips and human induced pluripotent stem cell–based disease models that form the basis of the project’s heart and neuromuscular organ-on-chip platforms. NMI also develops upgraded satellite products, including gene-edited cell lines for commercialization, and supports partners with expertise in recording and interpreting electrical and contractile activity of the miniaturised tissues. Finally, NMI leads the industrial qualification of the high-throughput PHOENIX platforms, validating them as reliable tools for drug safety testing and for evaluating new therapies for laminopathies and Friedreich’s ataxia in collaboration with clinical and industrial partners.

Main contributions and activities:

  • Development of advanced microelectrode-based organ-on-chip platforms and high-throughput assay formats for cardiac and neuromuscular disease modelling
  • Provision and optimisation of hiPSC-derived disease models, including gene-edited cell lines, combined with in-depth expertise in electrophysiological and contractility readouts
  • Industrial qualification and validation of the PHOENIX platforms as reliable tools for drug safety assessment and for evaluating novel therapies for laminopathies and Friedreich’s ataxia

Technologies & Capabilities

PHOENIX Project Team

Dr. Peter Jones – Microelectrode sensor chip development

Dr. Udo Kraushaar – Cardiac electrophysiology, assay development

Dr. Martin Kriebel – Generation of hiPSC derived disease model cell lines