Platforms & Demonstrators

A complete ecosystem of human-based platforms, satellite products, and clinical demonstrators designed to revolutionize drug discovery and disease modelling

1

The PHOENIX Platforms

Next-generation Organs-on-Chip integrating mechanical stimulation, electrophysiology, and force sensing

µHeart

Cardiac Platform

What it models: Human cardiac tissue function, recapitulating electrical and mechanical activity.

Core Technologies
3dMECH (mechanical stimulation), 3dMEA (electrophysiology), 3dFORCE (contractility)
Target Users
Academic research labs and R&D departments in Pharma/Biotech
µHeart Technical Diagram - Cross-section showing 3dMECH, 3dMEA, and 3dFORCE integration

µNMC

Neuromuscular Circuitry

What it models: The complex interaction between neurons and muscle fibers, including both afferent circuits (sensory neurons to muscle) and efferent circuits (motor neurons to muscle).

Core Technologies
3dMECH, 3dMEA, and 3dFORCE for functional neuromuscular readout
Target Users
Neurodegenerative disease researchers and drug developers
µNMC Technical Diagram - Bi-compartmental layout showing neuron-muscle interface

µSafeHeart

Safety Scaling - PHOENIX-SE

What it models: High-throughput cardiac safety and toxicology screening.

Core Technologies
Scalable screen-printed electronics for cost-effective electrical readout
Target Users
Pharma companies and CROs for routine screening

Platform Versions: From Research to Industry

Feature MVP (Prototype) Base/+ (Professional) Pro (Industrial)
Material Standard PDMS PDMS-free (no drug absorption) PDMS-free / Industrial Grade
Throughput Low (Research scale) Medium High (Automated screening)
Automation Manual Automation-compatible Full robotic integration
Readout Basic Electrical/Mech High-density 3dMEA/FORCE Real-time Big Data Analytics
2

Satellite Products: The Ecosystem

PHOENIX is not just the chip—it's a complete turnkey system for industrial-grade human-based modelling

uBox-4

The dedicated control unit for high-precision mechanical stimulation (3dMECH).

Flow Controller

An automated microfluidic system for precise media exchange and drug dosing, essential for long-term culture and "Pro" workflows.

Read-out Systems

Advanced hardware for high-density electrophysiological and contractility data acquisition (Base+ and Pro levels).

Gene-edited Cell Lines

Standardized healthy and diseased human iPSC lines, ensuring biological consistency across all experiments.

3

Clinical Demonstrators

Validating PHOENIX platforms on real human diseases, reducing reliance on animal models

LMNA-Cardiomyopathies

Background: A group of genetic heart diseases leading to arrhythmias and heart failure.

Why it's a good demonstrator: It requires the integration of both electrical and mechanical readouts to understand the disease mechanism.

Platform: µHeart
Lead: Humanitas (ICH)

Friedreich's Ataxia (FRDA)

Background: A rare genetic disease causing progressive nervous system damage and muscle weakness.

Why it's a good demonstrator: It allows for the study of the impaired communication between neurons and muscles in a controlled environment.

Platform: µNMC
Lead: CNR